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cba caj mice  (Jackson Laboratory)

 
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    Jackson Laboratory cba caj mice
    Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cba+caj+mice/caj+cba+mice/pm42129426-195-6-8
    Average 86 stars, based on 1 article reviews
    cba caj mice - by Bioz Stars, 2026-11
    86/100 stars

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    Related Articles

    Crocin Bleaching Assay:

    Article Title: Ultrastructural changes at auditory nerve synapses following moderate noise exposure
    Article Snippet: .. CBA/CaJ mice (Jackson Labs strain #000654) were bred in the animal facility in a quiet room. .. Control mice remained in the quiet room, and NE mice were kept in a separate room beginning at P21 with a Fostex FT28D speaker placed on top of the cage driven by an ACO Pacific white noise generator (model 3025).

    Article Title: A novel minimally invasive stereotaxic technique to target inner ear neurons in the mouse
    Article Snippet: .. 6–8-week-old CBA/CaJ mice (The Jackson Laboratory, RRID: IMSR_JAX:000654). ..

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction
    Article Snippet: .. Breeding pairs for CBA/CaJ mice were originally purchased from The Jackson Laboratory (JAX#000654) and bred at the MUSC Animal Research Facility. ..

    Article Title: Cortical representation of pitch perception in mice.
    Article Snippet: .. The mice were F1 offspring of CBA/CaJ mice (The Jackson Laboratory; stock #000654) crossed with transgenic C57BL/6J-Tg (Thy1GCaMP6s)GP4.3Dkim/J mice72 (The Jackson Laboratory; stock #024275). ..

    Article Title: A Newly Identified Role of the Tectorial Membrane in Aminoglycoside Ototoxicity
    Article Snippet: .. CBA/CaJ mice (Jackson Labs, 000654) were initially used in this study while breeding of Tecta Y1870C mice was taking place. ..

    Article Title: Circadian control of the peripheral vestibular organs in rodents and humans.
    Article Snippet: Circadian rhythms are fundamental for maintaining physiological homeostasis, influencing processes such as sleep-wake cycles, metabolism, and hormonal regulation.. The suprachiasmatic nucleus (SCN), the primary pacemaker in the brain, is necessary to maintain behavioral circadian rhythms and to synchronize peripheral clocks throughout the body in mammals.. The vestibular system, responsible for balance and spatial orientation, has been implicated in circadian regulation, yet its intrinsic clock machinery remains unexplored.

    Article Title: Oral AZD5438 is a clinically translatable otoprotectant against cisplatin-induced hearing loss
    Article Snippet: .. A multi-cycle cisplatin-induced ototoxicity mouse model was employed in CBA/CaJ mice (Strain #:000654, Jackson Laboratory [JAX], Bar Harbor, ME) with minor modifications from previously published methods [ ]. ..

    Article Title: Hormonal regulation of cochlear gene expression: effects of the estrous cycle, ovariectomy, and estradiol treatment.
    Article Snippet: .. Young, healthy female C57BL/6J and CBA/CaJ mice at the age of two months (The Jackson Laboratory, Bar Harbor, Maine, USA) were used in this study. ..

    Transgenic Assay:

    Article Title: Cortical representation of pitch perception in mice.
    Article Snippet: .. The mice were F1 offspring of CBA/CaJ mice (The Jackson Laboratory; stock #000654) crossed with transgenic C57BL/6J-Tg (Thy1GCaMP6s)GP4.3Dkim/J mice72 (The Jackson Laboratory; stock #024275). ..

    Immunocytochemistry:

    Article Title: Circadian control of the peripheral vestibular organs in rodents and humans.
    Article Snippet: Circadian rhythms are fundamental for maintaining physiological homeostasis, influencing processes such as sleep-wake cycles, metabolism, and hormonal regulation.. The suprachiasmatic nucleus (SCN), the primary pacemaker in the brain, is necessary to maintain behavioral circadian rhythms and to synchronize peripheral clocks throughout the body in mammals.. The vestibular system, responsible for balance and spatial orientation, has been implicated in circadian regulation, yet its intrinsic clock machinery remains unexplored.

    In Situ:

    Article Title: Circadian control of the peripheral vestibular organs in rodents and humans.
    Article Snippet: Circadian rhythms are fundamental for maintaining physiological homeostasis, influencing processes such as sleep-wake cycles, metabolism, and hormonal regulation.. The suprachiasmatic nucleus (SCN), the primary pacemaker in the brain, is necessary to maintain behavioral circadian rhythms and to synchronize peripheral clocks throughout the body in mammals.. The vestibular system, responsible for balance and spatial orientation, has been implicated in circadian regulation, yet its intrinsic clock machinery remains unexplored.

    RNAscope:

    Article Title: Circadian control of the peripheral vestibular organs in rodents and humans.
    Article Snippet: Circadian rhythms are fundamental for maintaining physiological homeostasis, influencing processes such as sleep-wake cycles, metabolism, and hormonal regulation.. The suprachiasmatic nucleus (SCN), the primary pacemaker in the brain, is necessary to maintain behavioral circadian rhythms and to synchronize peripheral clocks throughout the body in mammals.. The vestibular system, responsible for balance and spatial orientation, has been implicated in circadian regulation, yet its intrinsic clock machinery remains unexplored.

    Hybridization:

    Article Title: Circadian control of the peripheral vestibular organs in rodents and humans.
    Article Snippet: Circadian rhythms are fundamental for maintaining physiological homeostasis, influencing processes such as sleep-wake cycles, metabolism, and hormonal regulation.. The suprachiasmatic nucleus (SCN), the primary pacemaker in the brain, is necessary to maintain behavioral circadian rhythms and to synchronize peripheral clocks throughout the body in mammals.. The vestibular system, responsible for balance and spatial orientation, has been implicated in circadian regulation, yet its intrinsic clock machinery remains unexplored.



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    cba caj mice  (Jackson Laboratory)
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    Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) <t>(D-F)</t> <t>CBA/CaJ</t> mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.
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    male cba caj mice  (Jackson Laboratory)
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    Jackson Laboratory male cba caj mice
    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) <t>(D-F)</t> <t>CBA/CaJ</t> mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.
    Male Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cba+caj+mice/caj+cba+mice/pmc12812712-54-3-6
    Average 86 stars, based on 1 article reviews
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    Image Search Results


    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) (D-F) CBA/CaJ mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) (D-F) CBA/CaJ mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining, Marker

    (A –X) Serial sections taken 25 μm apart from tissue cleared mouse temporal bones showing the entire AN within the cochlea and the AN GTZ in a young (3 months) (A-L) and an aged (2.5 years) (M-X) CBA/CaJ mouse. (D’, E’, I’) Enlarged images of the white outlined regions of the AN GTZ in a young mouse are shown. (P’, T’, V’) Enlarged images of the white outlined regions of the AN GTZ in an aged mouse are shown with a white arrow indicating CD68 + cells within the AN, while no CD68 + cells were seen in the AN of the young mouse (D’, E’, I’). Dashed white lines in D’, E’, I’, and P’ show the cone-shaped morphology of the AN GTZ. Dashed white lines in T’ and V’ show the GTZ in the basal turn/hook of the cochlea. Each mouse temporal bone was stained with Myelin Basic Protein (green) and CD68 (red). Scale bars = 200 µm for all images.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A –X) Serial sections taken 25 μm apart from tissue cleared mouse temporal bones showing the entire AN within the cochlea and the AN GTZ in a young (3 months) (A-L) and an aged (2.5 years) (M-X) CBA/CaJ mouse. (D’, E’, I’) Enlarged images of the white outlined regions of the AN GTZ in a young mouse are shown. (P’, T’, V’) Enlarged images of the white outlined regions of the AN GTZ in an aged mouse are shown with a white arrow indicating CD68 + cells within the AN, while no CD68 + cells were seen in the AN of the young mouse (D’, E’, I’). Dashed white lines in D’, E’, I’, and P’ show the cone-shaped morphology of the AN GTZ. Dashed white lines in T’ and V’ show the GTZ in the basal turn/hook of the cochlea. Each mouse temporal bone was stained with Myelin Basic Protein (green) and CD68 (red). Scale bars = 200 µm for all images.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining

    (A-B) FluoroMyelin TM -stained sections in the peripheral AN (A) and central AN (B) in a young (3 months) and aged (2.5 years) CBA/CaJ mouse. Boxes on the top-right are enlarged images from the dashed boxes in A and B. (C) Quantification of myelinated AN fiber surface area in young (filled green circles) and aged (open green circles). N= 4 mice per age group. 4 ROIs per mouse (2 ROIs for peripheral AN, 2 ROIs for central AN). The difference between the young and the aged was not significant. (D-E) FluoroMyelin TM -stained sections in the peripheral AN (D) and central AN (E) in an aged CBA/CaJ mice. Magenta dashed boxes indicate the region of the pop-out image in the magenta outlined box. Boxes on the top-right are enlarged images from the dashed boxes in D and E. White arrows indicate the disrupted myelin sheaths in the peripheral AN (D) and central AN (E). (F) Quantification of myelinated AN fiber volume by age group. N = 4 mice per age group. 4 ROIs per animal. The difference between the young and the aged was not significant. Diamonds represent the mean and error bars represent the standard deviation for each group. All distributions were tested for normality using a Kolmogorov-Smirnoff test. Significance was determined using a Mann-Whitney U-test, α = 0.05. Scale bar = 10 µm for all images.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A-B) FluoroMyelin TM -stained sections in the peripheral AN (A) and central AN (B) in a young (3 months) and aged (2.5 years) CBA/CaJ mouse. Boxes on the top-right are enlarged images from the dashed boxes in A and B. (C) Quantification of myelinated AN fiber surface area in young (filled green circles) and aged (open green circles). N= 4 mice per age group. 4 ROIs per mouse (2 ROIs for peripheral AN, 2 ROIs for central AN). The difference between the young and the aged was not significant. (D-E) FluoroMyelin TM -stained sections in the peripheral AN (D) and central AN (E) in an aged CBA/CaJ mice. Magenta dashed boxes indicate the region of the pop-out image in the magenta outlined box. Boxes on the top-right are enlarged images from the dashed boxes in D and E. White arrows indicate the disrupted myelin sheaths in the peripheral AN (D) and central AN (E). (F) Quantification of myelinated AN fiber volume by age group. N = 4 mice per age group. 4 ROIs per animal. The difference between the young and the aged was not significant. Diamonds represent the mean and error bars represent the standard deviation for each group. All distributions were tested for normality using a Kolmogorov-Smirnoff test. Significance was determined using a Mann-Whitney U-test, α = 0.05. Scale bar = 10 µm for all images.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining, Standard Deviation, MANN-WHITNEY

    (A) Analysis of AN RNA-sequencing data from young (3 months) and aged (2.5 years) CBA/CaJ mice detects 1240 differentially expressed genes (Supplementary Table 1). (B) Enrichment analysis of differentially expressed genes detects significant effects on abnormal myelination and abnormal inflammatory response. (C) Expression patterns of differentially expressed genes linked to abnormal myelination, abnormal inflammatory response or both categories. For abnormal inflammatory response, the 15 genes showing highest upregulation are listed on the right.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A) Analysis of AN RNA-sequencing data from young (3 months) and aged (2.5 years) CBA/CaJ mice detects 1240 differentially expressed genes (Supplementary Table 1). (B) Enrichment analysis of differentially expressed genes detects significant effects on abnormal myelination and abnormal inflammatory response. (C) Expression patterns of differentially expressed genes linked to abnormal myelination, abnormal inflammatory response or both categories. For abnormal inflammatory response, the 15 genes showing highest upregulation are listed on the right.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: RNA Sequencing, Expressing